Probiotics For Oral Health? Our Probiotics For Oral Health R&D Center Research Papers

The New Paradigm
for Oral Management!
Oral Probiotics

OraPharm’s own research institute has its origins in the research on probiotics for oral health conducted by Dr. Oh Jong-Suk in the Medical School at Chonnam National Univ. in 1997. The team led by Dr. Oh believed that probiotics would play a promising role as a next-generation solution in oral management. They, therefore, isolated probiotic strains which have beneficial effects on oral disease prevention and management, adopted names for those strains, and finally found that those strains have great potential for becoming a solution in oral management.

To continue further research and buckle down to make oral probiotics commercially available, OraPharm was established in 2014 as a company specialized in probiotics for oral health. The company has employed core members of the research team led by Dr. Oh and has been doing various researches on the oral cavity ever since.

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An Area of Research:
Probiotics for Oral Health

Development of material that acts like human oral microbiome
An assessment of the efficacy and effects of oral probiotics
Expanded research on functions of oral probioticss
Engagement in researches designed or encouraged at the national level

Our Researches

Clinical Trials

59.4%

Reduction in bad breath
(46 participants,
Chonnam National Univ.)

J Clin Periodontol
2006;33:226-232
20.7%

Inhibition of plaque formation
(72 participants,
Chonnam National Univ.)

Caries Res
2006;40:418-425
18.4%

Plaque inhibition
(60 participants,
Kwangju Women’s Univ.)

Indian J Public Health.
2018;9(9):1163-1169
18.5%

Reduction of bacteria that cause dental caries
(60 participants,
Kwangju Women’s Univ.)

Indian J Public Health.
2018;9(9):1163-1169
Improvement of the

bad breath in 8 weeks
(60 participants,
Dankook Univ.)

Published results of the clinical trial directed by the College of Dentistry at Dankook Univ. in 2017
Improvement of the

bad breath in 8 weeks
(92 participants,
Kangwon National Univ.)

Published results of the clinical trial directed by the College of Nursing at KNU in 2018
Adhesive properties

Improved by 414%

after 8 weeks with

no probiotics intake
(60 participants,
Kwangju Women’s Univ.)

Indian J Public Health.
2018;9(9):1163-1169
Reduction in gingival

bleeding index in 8 weeks
(92 participants,
Kangwon Nation Univ.)

BMC Oral Health
2020

Preclinical Trials

Efficacy in the Suppression of Halitosis			Efficacy in the Prevention of Caries	Inhibition of the Growth of Bacteria That Cause Halitosis	Efficacy in the Adhesion in Oral Cavity	Efficacy in the Prevention of Periodontitis	Inhibition of Factors Causing Inflammation of the Gums
Organoleptic level of halitosis	Concentration of VSC	Concentration of CH₃SH	Dental plaque index	Bacteria associated with halitosis (Fn, Pg, Pi, Tf )	oraCMU (W.cibaria)	Alveolar bone loss	TNα,ILß,IL6
Suppressed by 40.5%	Suppressed by 37.3%	Suppressed by 52.6%	Reduced by 30.6%	Inhibited by 58.8%~99.6%	Increased by 70.6%	Suppressed by 26.9%	Decreased by 120%, 110%, and 130% respectively

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In Vitro Clinical Studies

Bacteria That Cause Halitosis·Periodontitis	Bacteria That Cause Periodontitis	Bacteria That Cause Dental Caries	Bacteria That Cause Halitosis·Periodontitis	Biofilm Formation Inhibition	Efficacy in the Suppression of Halitosis (containing VSC)	Efficacy in H₂O₂ Generation	Coaggregation
P. gingivalis	A. actinomy cetemcomitans	S. mutans	F. nucleatum	Biofilms formed by S. mutans	H₂S/CH₃SH	H₂O₂	Bacteria that cause halitosis·periodontitis (Fn, Td, Pi)
Suppressed by 99.9%	Suppressed by 99.9%	Suppressed by 97.7%	Suppressed by 96.6%	Inhibited by 96.8%	48.2%/59.4%	3.91 mM	66.5%~89.3%

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Public Engagement
with R&D Activities
in National Prejects

Date	Authorities Concerned	Name of the Project	Content
April 2020	The Ministry of Agriculture, Food and Rural Affairs	Development of technology for industrialization of valuable agricultural bioresources	Efficacy assessment and product development of oral probiotics to prevent upper respiratory infections
March 2018	Korea Industrial Technology Association	Support for university - corporate research institute collaborative R&D	Clinical trials for verification of efficacy of probiotics for oral health purposes & functional food product development
March 2018	Korea Institute of Startup & Entrepreneurship Development	Startup Scale-Up Package	Turning the use of oraCMU®, the probiotics for the prevention and removal of bad breath, and the finished product(Green Breath) into a business
December 2017	Korea Technology and Information Promotion Agency for SMEs	Program for technological development by industries, universities, and public research institutes working in collaboration	Verification of ingredients for the probiotics for the prevention and improvement of periodontal diseases and development of prototypes of functional food
December 2017	Korea Health Industry Development Institute	2017 Startup Scale-Up Package	Food and ingredients of probiotics for the prevention and improvement of halitosis
December 2017	Ministry of SMEs and Startups	Program for scaling up technological development	Verification of ingredients for the probiotics for the prevention and improvement of periodontal diseases and development of prototypes of functional food
July 2017	Kookmin University	BRIDGE +	Manufacturing a functional food product prototype, or more specifically, a probiotics prototype with anti-halitosis and anti-bacterial properties using Lean-DMADOV
July 2016	The Small and Medium Business Administration	Project to support the technology development and growth of startups	Development of next-generation probiotics for caries prevention
December 2015	Kookmin University	Prototype production support program by LINK+	Developing and manufacturing an oral probiotics prototype

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Date	Authorities Concerned	Name of the Project	Content
April 2020	The Ministry of Agriculture, Food and Rural Affairs	Development of technology for industrialization of valuable agricultural bioresources	Efficacy assessment and product development of oral probiotics to prevent upper respiratory infections

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Date	Authorities Concerned	Name of the Project	Content
April 2020	The Ministry of Agriculture, Food and Rural Affairs	Development of technology for industrialization of valuable agricultural bioresources	Efficacy assessment and product development of oral probiotics to prevent upper respiratory infections
March 2018	Korea Industrial Technology Association	Support for university - corporate research institute collaborative R&D	Clinical trials for verification of efficacy of probiotics for oral health purposes & functional food product development

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Date	Authorities Concerned	Name of the Project	Content
April 2020	The Ministry of Agriculture, Food and Rural Affairs	Development of technology for industrialization of valuable agricultural bioresources	Efficacy assessment and product development of oral probiotics to prevent upper respiratory infections
March 2018	Korea Industrial Technology Association	Support for university - corporate research institute collaborative R&D	Clinical trials for verification of efficacy of probiotics for oral health purposes & functional food product development
March 2018	Korea Institute of Startup & Entrepreneurship Development	Startup Scale-Up Package	Turning the use of oraCMU®, the probiotics for the prevention and removal of bad breath, and the finished product(Green Breath) into a business

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Papers

No	Citation	Journal	Research Level	Title	Date
1	SCI	Mol Med Rep. 2020;22:4143-4150.	in vitro study	Weissella cibaria CMU exerts an anti-inflammatory effect by inhibiting Aggregatibacter actinomycetemcomitans-induced NFκB activation in macrophages	2020.09
2	SCI	BMC Oral Health 2020;20:243.	Clinical trial	Effects of probiotic bacterium Weissella cibaria CMU on periodontal health and microbiota: a randomized, double-blind, placebo-controlled trial	2020.09
3	SCI	J Med Food. 2020;23(6).	Clinical trial	Reduction of halitosis by a tablet containing Weissella cibaria CMU: A randomized, double-blind, placebo-controlled study	2020.06
4	SCI	J Periodontol. 2020;3.	in vivo study	Effect of W. cibaria on the reduction of periodontal tissue destruction in mice	2020.02
5	KCI	Int J Oral Biol. 2019;44:152-159.	in vitro study	Weissella cibaria CMU suppresses mgl gene expression and enzyme activity associated with bad breath	2019.12
6	SCI	J Vet Dent. 2019;36(2):135-142.	in vivo study	Effects of Weissella cibaria CMU on Halitosis and Calculus, Plaque, and Gingivitis Indices in Beagles	2019.09
7	SCI	Int J Mol Sci. 2019;20(11).	in vitro study	Safety Evaluation of Oral Care Probiotics Weissella cibaria CMU and CMS1 by Phenotypic and Genotypic Analysis	2019.05
8	KCI	Int J Oral Biol 2018;43(4):193-200.	in vitro study	Effect of Natural Extracts on Oral Care Probiotics Weissella cibaria CMU and Periodontal Pathogens	2018.12
9	SCOPUS	Indian J Public Health Res&Dev. 2018;9(9):1163.	Clinical trial	Clinical studies on the dental caries prevention effects of the ability of Weissella cibaria CMU to adhere to the oral cavity	2018.10
10		J. Milk Sci. Biotechnol. 2018;36(3):171-177.	in vitro study	Enhancement of Viability of Weissella cibaria CMU by Low-Temperature Encapsulation	2018.09

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No	Citation	Journal	Research Level	Title	Date
11	SCI	Molecules 2018;23(8):1984.	in vitro study	Characterization of Antibacterial Cell-Free Supernatant from Oral Care Probiotic Weissella cibaria, CMU	2018.08
12	KCI	Korean J Vet Res. 2018;58(2):87-94.	in vivo study	Oral malodor-reducing effects by oral feeding of Weissella cibaria CMU in Beagle dogs	2018.05
13	SCOPUS	Genome Announc. 2017;5(40).	in vitro study	Complete Genome Sequences of Weissella cibaria Strains CMU, CMS1, CMS2, and CMS3 Isolated from Infant Saliva in South Korea	2017.10
14	SCI	Molecules. 2016;21(12).	in vitro study	Comparative Study on the Characteristics of Weissella cibaria CMU and Probiotic Strains for Oral Care	2016.12
15	KCI	Chonnam Med J. 2012;48(3):159-63.	in vitro study	Comparison of Temperature and Additives Affecting the Stability of the Probiotic Weissella cibaria	2012.12
16	KCI	J Bacterol Virol. 2011;41(1):17–26.	in vitro study	Effect of Weissella cibaria on Fusobacterium nucleatum-induced Interleukin-6 and Interleukin-8 Production in KB Cells	2011.03
17	KCI	J Bacterol Virol. 2009;39(4):1–11.	in vitro study	Quantitative analysis of Weissella cibaria Against Periodontopathic Bacteria by Real-time PCR	2009.12
18	SCI	FEMS Microbiol Lett. 2009;292(1):33-41.	in vitro study	Molecular characterization and expression analysis of the glucansucrase DSRWC from Weissella cibaria synthesizing a α(1→6)glucan	2009.01
19	SCI	Caries Res. 2006;40(5):418-25.	in vitro study clinical trial	Effect of Weissella cibaria Isolates on the Formation of Streptococcus mutans Biofilm	2006.08
20	SCI	J Clin Periodontol. 2006;33(3):226-32.	in vitro study clinical trial	Inhibitory effect of Weissella cibaria isolates on the production of volatile sulphur compounds	2006.02

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No	Citation	Journal	Research Level	Title	Date
21	KCI	J Bacterol Virol. 2006;36(3):151–157.	in vitro study	Adhesion of Weissella cibaria to the Epithelial Cells and Factors Affecting its Adhesion	2006.09
22	SCI	FEMS Microbiol Lett. 2005;253(2):323-9.	in vitro study	Coaggregation ability of Weissella cibaria isolates with Fusobacterium nucleatum and their adhesiveness to epithelial cells	2005.10

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Endeavoring to Include Various Functions

The research team in OraPharm studies not only oral diseases(halitosis, dental caries, periodontitis, etc.),
but also other various diseases including a sore throat, upper and lower respiratory diseases, and such.
We are well aware oral health is critical to one’s whole body health and healthy and happy life.
OraPharm continues researching to support everyone’s opportunities for a healthy life.

Teeth whitening
Prevention of
peri-implant
mucositis
Prevention &
treatment
of stomatitis
Strengthening
immune system
Prevention of
colpitis
Cosmeceuticals
(for acne prevention and treatment)

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